Kisk Cave is a location in Xenoblade Chronicles. It is located on the lower level of Bionis' Leg. It is a cave which leads to an elevated area where some Tirkins are found. There is also a Key Item here, the Bird Necklace, which is required for Search Quest 1. On the map, it is located south of Viliera Hill; however, its only entrance is actually east of the entrance to the Refugee Camp. Inside the cave is an Ether Deposit.

During Earnest's Fibs, Earnest tells the party that the Ether Deposit inside is everlasting. However, when it is examined, the party is attacked by a group of Vangs.